Glut4 And Diabetes
F and g: confocal imaging of glut4 and plasma membrane marker caveolin-3 (cav3) was performed on clamped (insulin-stimulated) gastrocnemius cryosections. quantification of sarcolemmal glut4 was performed by imagej. n = 11–15/group. h: vastus lateralis homogenates were applied to a 4–12% sds-page. western blotting was performed for hkii and. Glut4 has long been known to be an insulin responsive glucose transporter. regulation of glut4 has been a major focus of research on the cause and prevention of type 2 diabetes. understanding how insulin signaling alters the intracellular trafficking of glut4 as well as understanding the fate of glucose transported into the cell by glut4 will be critically important for seeking solutions to. Apr 23, 2018 · total glut4 content in skeletal muscle from individuals with type 2 diabetes is normal; however, recent studies have demonstrated that translocation of glut4 to the plasma membrane is decreased in response to insulin stimulation. The mechanism for...